Tea Party advocate and former Delaware senatorial candidate Christine O'Donnell stormed off Piers Morgan's set on Wednesday after being questioned on gay marriage.
O'Donnell became annoyed after Morgan questioned her on her witchcraft history, but became incensed to the point of leaving after the gay marriage line of questioning, according to Morgan.
"Ms. O'Donnell wasn't happy about me quizzing her re views on witchcraft and sex. But really flipped at gay marriage Qs. Ripped mike and fled," Morgan tweeted after the taping.
During the interview O'Donnell stated she was not running for office and for Morgan to ask presidential candidate Michele Bachmann about gay marriage.
O'Donnell was on the show to promote her new book, "Troublemaker.
She inflicted a shock defeat on Mike Castle, the mainstream Republican candidate, who had served nine terms in the US House of Representatives after being governor of the state.
But in the general election, she turned a race that had looked winnable to many Republicans into a thumping victory for her Democratic opponent, Chris Coons, who won by 57 per cent to 40 per cent.
The defeat, blamed by some on her Right-wing positions on social issues alienating independent voters, also came at the end of a campaign that lurched from one public relations disaster to the next.
Bill Maher, a Left-wing television host, dug out footage of Miss O'Donnell on his show in 1999 saying that she had "dabbled into witchcraft". The remark received widespread media attention.
Serious questions were soon raised about Miss O'Donnell's education record, tax returns and handling of campaign funds. She denied any wrongdoing.
Then more footage emerged of Miss O'Donnell fronting an anti-masturbation campaign in the 1990s, when she publicly declared that she believed it to be "a sin".
Despite being classed, along with other Right-wing women politicians such as Sarah Palin, Michele Bachmann and Kristi Noem, as a "Mama Grizzly", she attempted to play down her views on such issues.
Ultimately, however, she alienated the relatively moderate voters of Delaware to such an extent that Mr Obama's Democrats avoided the loss of another seat in the Senate, of which they retained control.
Born in Philadelphia, Pennsylvania, in August 1969, Miss O'Donnell has said she grew up a liberal before becoming a born-again Christian while studying at Fairleigh Dickinson University.
She worked as a Republican campaigner in the 1990s before joining various anti-aborition and pro-creationist not-for-profit groups and becoming a television commentator.
She then set up her own media consultancy before making three attempts at the Delaware senate seat. In 2006 she finished third in the Republican primary. In 2008 she lost the general election to Mr Biden.
Her book 'Troublemaker: Let's Do What It Takes To Make America Great Again' has recently been published. She has declined to say whether she plans to run for office again.
